Yes
Using event code.
Assuming column B cells are unlocked and the sheet is protected with
password "justme", as you enter data in column B, the cell will become
locked.
Private Sub Worksheet_Change(ByVal Target As Excel.Range)
On Error GoTo enditall
Application.EnableEvents = False
If Target.Cells.Column = 2 Then
ActiveSheet.Unprotect Password:="justme"
N = Target.Row
If Excel.Range("B" & N).Value <> "" Then
Excel.Range("B" & N).Locked = True
End If
End If
enditall:
ActiveSheet.Protect Password:="justme"
Application.EnableEvents = True
End Sub
This is sheet event code. Right-click on the sheet tab and "View Code".
Copy/paste the code into that module.
I'm sure your needs are not exactly as per sample above.
If you provide more detail perhaps code could be tailored.
Gord Dibben MS Excel MVP