Your first message hinted that you wanted to place an image in the center page,
in a 4 page setup this would mean the picture would expand pages 2 and 3. It
shouldn't matter what your margins are, it would be the same as placing a
picture on a regular landscape piece of stock.
Is your page setup for a booklet?
Now if you have, let's say, eight pages, and you want the picture centered on
pages 2 and 3, there are procedures you have to go through. Be sure you are
viewing a two page spread. Copy your image, paste, align the two images
precisely, one on top the other. With the cropping tool, crop the top image left
to the center of the page, select the bottom image and crop right to the center
of the page. It should print correctly even with tabloid stock.