Check my reply to "PUB to PDF" in this newsgroup. I suggest the use of a PDF
Writer such as CutePDFEvl.exe. You can still find it on the web.
I have recently completed a 250 page book with many graphics, many fonts,
many master pages, full auto TOC, full colour cover pages, etc., etc.
CutePDF created a 215 MB file. No trouble at all, but pay attention to my
other comments on "Download as Softfonts". If you don't download the fonts,
the fonts don't get inluded in the PDF file, and the commercial printer may
not print the fonts you want.
Our Commercial Printer sent our file to their printer with "No Scaling".
And again no problems.
Too bad the book doesn't selling as fast as we want, but I think that's
another matter. Hope this helps.