There is some overhead to having that many fonts. When you choose a Font
dropdown in Word, for example, it takes time to populate the list. At one
point, I was a fan of "more is better." Now, however, I have the default
fonts that come with various programs I've installed. But, unless I need
something for a project/client, I don't bother.
It's a lot like cable versus over-the-air programming. Way back when I had
10 channels to choose from, it took about 2 minutes to quickly determine
that there was nothing on worth watching. When I had 160 cable channels, it
took an hour to reach the identical conclusion.
Now that we don't have cable, I save a lot of time. ;-)