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Message: [QUOTE="Localboy, post: 6807071"] I've started having the same problem in the last few weeks. I'm using Excel for Mac 10.1.9 which as far as I know is the latest for Mac Office v.X. (I never upgraded to Mac Office 2004 figuring I'd wait for the Intel native upgrade. However, since Mac Office 2008 didn't support VBA I had to remain with v.X since I rely heavily on macros in Word and Excel.) I have found through trial and error that trashing any of the following files in my Username/Library/Preference/Microsoft directory corrects the issue temporarily and allows Excel to launch: • Carbon Registration Database • Office Font Cache (10) • Office Registration Cache Once I quit Excel, one of these files needs to be deleted to launch Excel again. It doesn't seem to matter which one. I put an alias to the Microsoft preference folder in my user home folder to make that easy to do. Word and Powerpoint are unaffected by this problem and launch properly. I'm using an iMac G5 PPC 2 GHz with 1 GB of RAM, Mac OS X 10.5.5. It looks like Out of Memory is a common problem in Excel for Mac judging by the number of postings on the subject. Hope this helps. [/QUOTE]