Absolutely.
Concatenate your data into one column and make sure that the resulting data
is also a cell in the left column of your look-up array (table range).
For example: IF cell B1 contains an "A" and C1 contains a "B" and D1
contains "C" and you need to lookup "ABC", then in column A1 enter the
concatenating forumla:
=B1&C1&D1
to get "ABC".
Now, assuming there is a cell with "ABC" in the left column of the lookup
range, BINGO ... your vLookUp formula will work.
Good Luck.